Cue Set
Cue Set
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What causes alcoholic hyaline (mallory bodies) in hepatocytes?
I know mallory bodies are typically found in the hepatocytes of alcoholics (but also in other liver pathologies) and that they are eosinophillic skeins of cytokeratin intermediate filaments and other proteins...but does any one have any reason why/how the form? Like what cellular/environmental cue sets off their formation?
well from my reading on the internet, the cause is unknown, but one research paper from Japan:
"Mallory bodies (MBs) are intracytoplasmic bodies seen in hepatocytes of alcoholic liver
disease, primary biliary cirrhosis and hepatocellular carcinoma. However, the mechanism
of MB formation has not been fully understood. Proteins could be modified to advanced
glycation end products (AGEs) after long-term incubation with reducing sugar.
AGEs are known to accumulate in several tissues in aging and age-enhanced disorders.
To study the possible glycation process in the formation of MBs, hepatocytes..."
Masako Kato, Shinsuke Kato*, Seikoh Horiuchi†, Ryoji Nagai†, Yasushi Horie and
Kazuhiko Hayashi‡
Pathology Division, Tottori University Hospital, Yonago 683-8504, *Department of Neuropathology,
Institute of Neurological Sciences, Tottori University Faculty of Medicine, Yonago 683-8504,
†Department of Medical Biochemistry, Graduate School of Medical and Pharmaceutical Sciences,
Kumamoto University, Department of Biochemistry, Kumamoto University School of Medicine,
Kumamoto 860-0811 and ‡Division of Molecular Pathology, Department of Microbiology
and Pathology, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503
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